The CKD-REIN study is the first large cohort study conducted in France on a representative sample of patients with chronic kidney disease. The aim is to better understand the causes, factors of progression and consequences of this disease in order to identify and promote the most appropriate prevention and management strategies. Between 2013 and 2016, 3033 volunteer patients of legal age, attending 40 nephrology consultations, were included in the study after their informed consent was obtained and are currently undergoing an active 5-year annual follow-up. Data from the SNDS (French national health data system) will be used mainly to enrich the CKD-REIN database with information on healthcare consumption and to quantify expenditures, as well as to extend the follow-up of patients beyond 2020, by means of a passive follow-up based on variables indicating health events or treatments derived from the SNDS and validated during the first stage of the follow-up.