As part of Inserm’s Genomic Variability transversal program, also known as GOLD for GenOmics variability in heaLth & Disease, the GOLD-GENOPHENOMET project relies on genetic data from volunteers in the Constances cohort, generated as part of the France Médecine Génomique 2025 POPGEN pilot project, and made securely available to CASD.
The aim of this project is to evaluate statistical and bioinformatics methods to gain a better understanding of the impact of genetic variations on health, so as to be able, if possible, to implement more effective measures in the care of the population.
To achieve this, a specific work environment, enabling programming in a wide range of languages (C/C++, java, Perl, python, bash, awk) and with domain-specific software (Plink, LDPred2, snptest, bolt-lmm, etc.), was installed in a dedicated secure bubble running under Linux, accessible after authentication on an SD-Box from the environment conventionally made available at CASD.
